Table 1.
Quantitative readouts for uterine and mammary gland effects of MPA and drospirenone
| Readout | MPA (mg/kg)a | Drospirenone (mg/kg)a |
|---|---|---|
| Uterus | ||
| Maintenance of pregnancy, ED50 | 3.6 (2.2, 6.0) | 25.8 (16.0, 31.6) |
| BrdU incorporation in epithelial cells, mean ID100 | 2.9 | 17.5 |
| Inhibition of E2-induced LTF expression, ID50 | 0.7 (0.5, 1.0) | 22.0 (3.6, 32.1) |
| Mammary gland | ||
| Formation of side branches, ED50 | 4.3 (2.0, 7.5) | 69.4 (60.3, 84.3) |
| BrdU incorporation in epithelial cells, ED50 | 1.2 (0.3, 4.2) | 50.5 (40.9, 64.0) |
| Inhibition of E2-induced INDO expression, ID50 | 0.09 (0.07, 0.13) | 14.1 (3.3, 19.5) |
| Cyclin D1 expression, first significant effect | 0.75 | 180 |
| RANKL expression, first significant effect | 0.75 | 180 |
E2, 17β-Estradiol.
a
The 95% confidence intervals are shown in parentheses.