Figure 2.

Effects of VDR activators on CKD-induce gene expression in aortas of LDLR−/− high fat–fed mice: (A) osterix. (B) Msx2. (C) CBFA1/RUNX2. (D) osteocalcin. Calcitriol 20 ng/kg and paricalcitol 50 and 100 ng/kg all decreased CKD-induced gene expression. Paricalcitol 400 ng/kg had no effect on CKD-stimulated RUNX2 expression, although it inhibited osteocalcin probably by inhibition of osterix and Msx2 expression. Note that the scale of the y axis was adjusted for the high levels of osteocalcin.