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Effects of VDR activators on bone formation rates (bfr/bs) in mm3/m2 per yr in LDLR−/− high fat–fed mice with CKD and ABD. Bone formation rates were decreased in the sham-operated, high fat–fed group and the baseline and untreated CKD groups compared with sham-operated chow-fed animals. Calcitriol at 10 ng/kg and paricalcitol at 100 ng/kg increased bone formation rates.
