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Effects of VDR activators on the serum Pi in LDLR−/− high fat–fed mice with CKD. CKD produced hyperphosphatemia in the baseline (22 wk) and untreated groups (28 wk). The hyperphosphatemia tended to be ameliorated by treatment with the VDR activators, and calcitriol 20 ng/kg and paricalcitol 100 ng/kg significantly reduced serum Pi levels.
