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. 2008 Aug;19(8):1509–1519. doi: 10.1681/ASN.2007080902

Table 1.

Biochemical parameters in the various groups of animals

Parameter Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Group 7 Group 8 Group 9 Group 10
Mouse strain C57BL6(wild-type) LDLR−/− LDLR−/− LDLR−/− LDLR−/− LDLR−/− LDLR−/− LDLR−/− LDLR−/− LDLR−/−
Diet Regular chow Regular chow High fat Fat Fat Fat Fat Fat Fat Fat
Surgery Sham Sham Sham CKD CKD CKD CKD CKD CKD CKD
Weeks postnatal 28 28 28 22 28 28 28 28 28 28
Treatment Vehicle Vehicle Vehicle Vehicle Vehicle Calcitriol 10 ng/kg Calcitriol 20 ng/kg Paricalcitol 50 ng/kg Paricalcitol 100 ng/kg Paricalcitol 400 ng/kg
n 7 7 7 6 7 6 6 10 8 9
Presurgical weight 18.983 ± 1.010 19.314 ± 0.640 19.400 ± 0.620 21.740 ± 0.750 21.500 ± 1.890 22.120 ± 2.180 21.400 ± 0.835 21.020 ± 0.676 21.988 ± 1.089 22.378 ± 0.691
Weight at killing 21.583 ± 0.759 20.580 ± 0.500 25.044 ± 1.640 21.640 ± 0.950 21.067 ± 1.800 22.600 ± 1.860 24.383 ± 1.807 22.580 ± 1.039 22.938 ± 1.327 24.933 ± 1.205
BUN (mg/dl) 20.960 ± 2.896 27.660 ± 4.640 18.700 ± 1.660 61.200 ± 14.460a 37.420 ± 3.740a 54.000 ± 10.000a 46.400 ± 3.280a 38.140 ± 4.890a 49.660 ± 2.690a 38.710 ± 5.720a
Glucose (mg/dl)b 148.410 ± 12.780 233.500 ± 20.790 155.900 ± 24.480 124.800 ± 16.850 165.430 ± 14.700 207.870 ± 41.260 181.400 ± 25.880 184.430 ± 26.240 174.500 ± 32.910 288.140 ± 52.790
Cholesterol (mg/dl) 52.360 ± 4.600 199.00 ± 6.800 658.900 ± 78.000c 556.000 ± 70.000c 702.500 ± 72.00c 466.620 ± 50.600c 790.800 ± 167.550c 814.000 ± 90.720c 593.500 ± 81.590c 1213.2008 ± 143.550c
PTH (pg/ml) 19.100 ± 5.300 25.630 ± 6.300 23.510 ± 13.360 743.520 ± 186.000d 444.050 ± 98.000d 74.600 ± 8.300e 44.320 ± 9.600e 83.710 ± 18.800e 60.340 ± 19.200e 16.200 ± 2.700e
a

All of the CKD groups had significantly higher BUN at killing compared with wild-type or high-fat sham (P < 0.02).

b

There was no statistical difference among the glucose values.

c

All the high fat–fed groups had significantly higher cholesterol compared with wild-type (P < 0.001).

d

The PTH values were higher for the CKD groups compared with wild-type (P < 0.001).

e

There was a dosage-dependent decrease in PTH compared with the CKD 28-wk vehicle group (untreated; P < 0.001).