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. 2008 Aug;19(8):1463–1471. doi: 10.1681/ASN.2007101138

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Copyright © 2008 by the American Society of Nephrology

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Figure 5. — Localization of PV-1 in GEnC of immature and Thy-1.1 nephritic glomeruli. Localization of PV-1 was examined in GEnC by the use of immunogold electron microscopy. (A through E) E18 rat embryos. Immunogold labelings for PV-1 are predominantly localized at stomatal diaphragms of caveolae (arrows in A and B) and fenestral diaphragms (arrowheads in C and D). Immunogold labelings for PV-1 are also localized at the fenestral diaphragms of pored dome, which form a fenestrated cytoplasmic sheet that protrudes into capillary lumen (arrowheads in E). (A and B) S-shaped body stage. (C through E) Maturing glomerulus stage. (F through H) Thy-1.1 nephritis rats (day 8). Immunogold labelings for PV-1 are predominantly localized at fenestral diaphragms (arrowheads in F and G) and stomatal diaphragms of transendothelial channel (arrows in H). All of the micrographs are of the same magnification. Bar = 200 nm.