Figure 8.

Diagram showing the state of fenestrae and caveolae in GEnC of immature and Thy-1.1 nephritic glomeruli. (A) In the S-shaped body stage, GEnC possess a relatively large number of diaphragmed caveolae (short arrowheads). Nondiaphragmed fenestrae and caveolae are not found in this stage. (B) In the maturing glomerulus stage, GEnC frequently exhibit transendothelial channels with two diaphragms (arrow), diaphragmed fenestrae (long arrowheads), and nondiaphragmed fenestrae. (C) In completely mature stage, diaphragms are diminished from fenestrae and caveolae in most GEnC. (D) In Thy-1.1 nephritic glomeruli, the GEnC with diaphragmed fenestrae and caveolae are significantly increased in comparison with those of normal mature glomeruli.