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Rapamycin started on the day of immunization modulates renal mRNA expression of IFN-γ, TNF-α, and IL-6. The expression of TNF-α, IFN-γ, IL-6, and IL-10 mRNA was evaluated by real-time PCR of total RNA from kidneys of mice treated with rapamycin (□; n = 8) or vehicle (▪; n = 7) 21 d after anti-GBM injection. Rapamycin treatment starting on the day of immunization significantly reduced mRNA expression of IFN-γ, TNF-α, and IL-6 in the kidneys but not for IL-10. *P < 0.05.
