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IgG production is significantly inhibited by rapamycin treatment starting on the day of immunization. Mouse anti-rabbit IgG was evaluated in rapamycin- (□; n = 8 per time point) and vehicle-treated (▪; n = 7 per time point) on day 14 and 21 after anti-GBM injection. Concentrations of mouse anti-rabbit IgG were significantly diminished in rapamycin-treated mice at all tested time points. *P < 0.05.
