Figure 6.

Transgenic Drosophila expressing full-length APP derivatives develop a blistered-wing phenotype. Flies expressing APP695, APP695-Swedish, or APP695/APLP2-N-myc develop abnormal wings with distinct blisters. Two examples are shown with different extents of the wing phenotype. (A) A round blister in the proximal part of the wing is shown. (B) In the most severe phenotype, the two epithelial wing-cell layers are not connected anymore. The whole wing looks like a black balloon filled with hemolymph.