Table 3.
Performance of combinations of candidate biomarkers
| Combination | TP | FP | TN | FN | sensitivity (HCC = 50) | specificity (LC = 41) | TPP | TPN | LR |
| afp | 28 | 0 | 41 | 22 | 56.00% | 100.00% | 100.0% | 65.10% | - |
| afp+piv | 47 | 8 | 33 | 3 | 94.00% | 80.50% | 85.50% | 91.70% | 4.82 |
| piv | 39 | 8 | 33 | 11 | 78.00% | 80.50% | 83.00% | 75.00% | 4 |
| afp+scca | 36 | 11 | 30 | 14 | 72.00% | 73.20% | 76.60% | 68.20% | 2.68 |
| afp+piv+scca | 45 | 16 | 25 | 5 | 90.00% | 61.00% | 73.80% | 83.30% | 2.31 |
| piv+scca | 42 | 16 | 25 | 8 | 84.00% | 61.00% | 72.40% | 75.80% | 2.15 |
| gcp+scca | 36 | 16 | 25 | 14 | 72.00% | 61.00% | 69.20% | 64.10% | 1.85 |
| afp+gcp | 41 | 22 | 19 | 9 | 82.00% | 46.30% | 65.10% | 67.90% | 1.53 |
| afp+piv+gcp | 48 | 27 | 14 | 2 | 96.00% | 34.10% | 64.00% | 87.50% | 1.46 |
| gcp+piv | 46 | 27 | 14 | 4 | 92.00% | 34.10% | 63.00% | 77.80% | 1.4 |
| all | 48 | 31 | 10 | 2 | 96.00% | 24.40% | 60.80% | 83.30% | 1.27 |
| gcp | 34 | 22 | 19 | 16 | 68.00% | 46.30% | 60.70% | 54.30% | 1.27 |
| gcp+piv+scca | 47 | 31 | 10 | 3 | 94.00% | 24.40% | 60.30% | 76.90% | 1.24 |
| afp+gcp+scca | 36 | 28 | 13 | 14 | 72.00% | 31.70% | 56.30% | 48.10% | 1.05 |
| scca | 9 | 11 | 30 | 41 | 18.00% | 73.20% | 45.00% | 42.30% | 0.67 |
The true and false positive (TP and FP), as well as true and false negative (TN and FN) for each candidate either alone or in combination is presented, along with sensitivity, specificity, true percentage positive (TPP) and true percentage negative (TPN) values and the liklihood ratio (LR). The LR is the ratio of true and false positives (sensitivity and 1-specificity respectively), where higher values reflect the probability of a better performance.