Figure 1.

a) Co-conserved protein-protein interaction network of E. coli K12 using All bacteria as the reference genome set. Nodes are colored based on KEGG functional category. Note co-conservation based interactions occur between proteins that function in related processes. Metabolism (pink); Genetic Information Processing (red); Environmental Information Processing (blue); Cellular Processes (green); Unclassified (yellow); Unclassified in KEGG, COG and TIGR (diamond); b) Connectivity distribution of co-conserved protein-protein interactions: b) connectivity (k) versus p(k); c) log connectivity (k) versus log p(k).