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. 2008 Aug 13;3(8):e2924. doi: 10.1371/journal.pone.0002924

Figure 2. Francisella-induced changes in IFNγ pathway-related genes.

Figure 2

A. List of IFN, Jak and SOCS genes regulated by Francisella infection (both F. novicida and Schu S4) from the microarray analysis. Fold changes of genes not statistically different are denoted “NS”. B. Real-time PCR of IFNγ, SOCS1 and SOCS3 from human PBM infected with either F. novicida (“FN”) or Schu S4 (“S4”) at 100 MOI for 24 hours (n = 8). “RCN” is Relative Copy Number for the Y axis. Asterisks denote statistical significance (p≤0.05) versus uninfected. C. Flow cytometry for the IFNγ receptor following F. novicida infection of human monocytes. The data are representative of three independent experiments.