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Limb defects. (A–C) Polydactyly and polysyndactyly in forelimbs of E18.5 AP-2 chimeras. (D) Extra forepaw in E18.5 chimera. (E) Skeletal staining of forelimb shown in D. (F) Duplication of the humerus (h), resulting in an additional forelimb.
