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. Author manuscript; available in PMC: 2009 Jul 3.
Published in final edited form as: Org Lett. 2008 Jun 4;10(13):2721–2724. doi: 10.1021/ol8008792

Table 3.

Substrate Scope of the Cu-Catalyzed Domino Amidation Reaction

graphic file with name nihms55910f6.jpg
entry product yielda
1 graphic file with name nihms55910t5.jpg 3e 75%
2 graphic file with name nihms55910t6.jpg 3f 82%
3 graphic file with name nihms55910t7.jpg 3g 95%
4 graphic file with name nihms55910t8.jpg 3h 95%
5 graphic file with name nihms55910t9.jpg 3i 92%
6 graphic file with name nihms55910t10.jpg 3k 96%
7 graphic file with name nihms55910t11.jpg 3l 88%
8 graphic file with name nihms55910t12.jpg 3m 91%
9 graphic file with name nihms55910t13.jpg 3n 74%
10 graphic file with name nihms55910t14.jpg 3o 76%
11 graphic file with name nihms55910t15.jpg 3p 57%
a

Yields of the isolated products are an average of two runs and the products are estimated to be over 95% pure by 1H NMR spectroscopic and GC analysis.