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. 1998 Nov 10;95(23):13806–13811. doi: 10.1073/pnas.95.23.13806

Figure 1.

Figure 1

IFN-γ primes for enhanced IL-12 production, but inhibits MIP-1α and MIP-1β production. Thioglycollate-elicited peritoneal macrophages were incubated with 500 units/ml of IFN-γ simultaneously with or 16 hr before the addition of 100 μg/ml of LMW-HA, which was added for an additional 16 hr. Supernatants were harvested and analyzed for IL-12 p40 and IL-12 p70 production by RIA and for MIP-1α and MIP-1β production by ELISA. Data are expressed as the mean ± SD. Similar results were obtained in three independent experiments. ∗, P < 0.05 compared with cells stimulated with HA alone (t = 16–32 h).