Table 3.

A-Max inhibits Myc-dependent transformation

Groups	Relative focus formation
Ras	0.34
Ras + Myc	1.00
Ras + Myc + wt Max	0.96
Ras + Myc + Δ-Max	0.80
Ras + Myc + A-Max	0.59
Ras + Myc + Δ-Max-C	0.56
Ras + Myc + A-Max-C	0.28
Ras + Myc + A-Mitf	0.77

C3H10T1/2 cells were transfected with expression vectors for the activated human H-ras oncogene (Ras) and the v-myc oncogene (Myc) (18, 23). A 3-fold molar excess (relative to Myc) of expression vectors for wild-type (wt) Max (pEMscribe Max) and potential D-Ns were added, and focus formation was assessed. A number of foci in each set of experiments was normalized to the number of foci in Ras + Myc plates to produce relative focus formation. Relative focus formation was averaged for five sets of experiments.