Table 1.

Effects of PPARα ligands on COX-2 signaling.

PPARα ligand	Action/effect	References
Wy-14643
	Inhibition of IL-1-induced COX-2 expression in vascular smooth muscle cells	[25]
	Inhibition of LPS-induced COX-2 expression in THP-1 monocytes	[94]
	Inhibition of TPA-induced COX-2 expression in colon carcinoma cell lines	[30]
	Inhibition of COX-2 expression in B16-F10 melanoma tumor	[49]
	Inhibition of COX-2 up regulation by experimental steatohepatitis in liver	[95]
Fenofibrate
	Inhibition of COX-2 expression in B16-F10 melanoma tumor	[49]
	Inhibition of b-FGF induced COX-2 expression in endothelial cells	[65]
Clofibric acid
	Inhibition of COX-2 expression in tumor xenografts	[58]
	Inhibition of mPGES-1 expression in tumor xenografts	[59]