Table 4.
UA treatment of MBP-immunized PLSJL mice during the first seven days after immunization decrease incidence of paralytic EAE and suppress mortality.
| Incidence of paralytic EAE (%) (score > 2) | % mortality | |
|---|---|---|
| UA treated mice | 28.6 | 0 |
| Saline treated mice | 52.6 | 21.1 |
PLSJL mice were immunized and treated for 7 days with UA (14 mice) or saline (19 mice) as described in a legend for figure 6B. Disease development was monitored for 30 days. Data are represented as percent of mice showing clinical signs of EAE or as a percent mortality.