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. 2008 Jul 16;4:26. doi: 10.1186/1744-8069-4-26

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Copyright © 2008 Fu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A cAMP antagonist (cAMPS-Rp) inhibits synaptic plasticity but not normal synaptic transmission. Monosynaptic EPSCs were evoked at the PB-CeLC and BLA-CeLC synapses in slices from normal (A, C) and arthritic (6 h postinduction; B, D) rats. cAMPS-Rp (10 μM, 15 min) inhibited synaptic transmission in neurons from arthritic rats 6 h postinduction (D, n = 6; P < 0.05, paired t-test) but not in control neurons from normal rats (C, n = 4). (A, B) Original recordings of EPSCs (average of 8–10 EPSCs) evoked at the two synapses. (C, D) Averaged EPSC amplitudes (mean ± SE) in the presence of cAMPS-Rp normalized to predrug control values (set to 100%). Whole-cell voltage-clamp recordings were made at -60 mV. * P < 0.05.