Table 3.
GERD health-related quality of life scores and symptoms
| Parameter | Pre–TIF (n = 82) | 6 Months Post-TIF (n = 81) | 12 Months Post-TIF (n = 79) |
|---|---|---|---|
| GERD-HRQL score | |||
| Median (range) off PPIs | 24 (11–38) | 5 (0–24) | 7 (0–30) |
| Median % reduction vs. pre-TIF off PPIs | 80% | 68% | |
| p | <0.0001 | <0.0001 | |
| No. reduced by ≥50% | 62 (77%) | 58 (73%) | |
| No. eliminated | 65 (80%) | 59 (75%) | |
| Median (range) on PPIs | 9 (0–22) | – | – |
| Median % reduction vs. pre-TIF on PPIs | 50% | 22% | |
| p | <0.05 | >0.05 | |
| Heartburn score | |||
| Median (range) off PPIs | 21 (10–30) | 4 (0–19) | 6 (0–26) |
| Median % reduction vs. pre-TIF off PPIs | 79% | 67% | |
| p | <0.0001 | <0.0001 | |
| No. reduced by ≥50% | 62 (77%) | 59 (75%) | |
| No. eliminateda | 70 (86%) | 61 (77%) | |
| Median (range) on PPIs | 7 (0–19) | – | – |
| Median % reduction vs. pre-TIF on PPIs | 43% | 22% | |
| p | <0.05 | >0.05 | |
| Regurgitation | |||
| No. off PPIs | 60 (74%) | 24 (30%) | 25 (32%) |
| No. eliminated | 37 (62%) | 34 (59%) | |
HRQL: health-related quality of life; TIF: transoral incisionless fundoplication
aDefined by a total score of ≤12 with each of the six questions evaluated as rare (score ≤2)