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. 2008 Jun 27;36(13):4381–4389. doi: 10.1093/nar/gkn412

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Stretching of DNA held with one side in an optical trap using continuous flow. (A) Schematic of the assay. DNA is attached to a bead with one end, the bead is held in an optical trap. To overcome the entropic forces that keep the DNA compact a continuous solvent flow is applied extending the DNA. DNA or associated proteins can be visualized using fluorescence microscopy. (B) Application of this assay to the formation of RecA filaments (40). λ-DNA is incubated with fluorescent RecA and filament formation is monitored by fluorescence. Note the increase of the length of the DNA due to RecA binding. Adapted by permission from Macmillan Publishers Ltd: Nature (40), copyright 2006.