TABLE 2.

Potential endocytic signals in HARE The candidate endocytic signals (M1–M4) in the HARE CD, their recognition partners, and potential functions are summarized. The first motif contains two overlapping YXXΦ motifs as indicated by the sequences that are underlined or in boldface font.

HARE sequence	Targeting motif	Proposed recognition protein	Function	Refs.
YSYFRI2485	YXXΦ (ΦXXB)	μ subunits of AP complex	Internalization, basolateral, or lysosomal targeting	43, 44, 59–62
FQHF2495	ΦXXB	μ subunits of AP complex	Internalization, basolateral, or lysosomal targeting	43, 44, 59–62
NPLY2519	NPXY	μ2 subunit of AP-2, Dab2 Tyr(P) binding domain, clathrin	Internalization, intracellular, routing/signaling	42, 47, 49, 50
DPF2534	DPF/DPW	Ear domain of the α subunit of AP-2 complex	Internalization process	34, 35, 37