Table 2.
Inefficient survival of NOD splenocytes injected into NODlpr recipients
| Transfer protocol, donor to recipient* | Total no. of CFSE+ cells in spleen | No. of CFSE+ CD4+ T cells in spleen | No. of CFSE+ CD8+ T cells in spleen | No. of CFSE+ B220+ B cells in spleen |
|---|---|---|---|---|
| At day 1 | × 106 | × 104 | × 104 | × 104 |
| NOD to NOD | 1.0 (1–1.2) | |||
| NOD to lpr | 0.7 (0.5–0.9) | |||
| lpr to lpr | 1.5 (1.3–1.9) | |||
| At day 4 | ||||
| NOD to NOD | 1.0 (0.9–1.3) | 15 (12–16) | 6 (5–7) | 52 (25–80) |
| NOD to lpr | 0.2 (0.2) | 1.6 (1.5–1.8) | 1 (1) | 12 (11–15) |
| lpr to lpr | 1.2 (1.1–1.4) |
*
Mice were injected with 2 × 107 CFSE-labeled splenocytes from nondiabetic NOD or NODlpr donors. Results represent the average from three mice, with the range given in parentheses.