Figure 5.

Renal abnormalities in GP73^tr/tr mice. Whole kidneys from GP73^+/+ (A), and GP73^tr/tr (B) mice. Photomicrographs of kidney sections from GP73^+/+ (C), and GP73^tr/tr (D-H) mice stained with H&E and PAS. GP73^tr/tr mice developed glomerulosclerosis (arrowheads) and intratubular casts (arrowhead, D), formation of PAS-positive hyaline thrombi (arrowheads, E), degenerative changes in proximal collecting tubules (arrowheads, F), glomerular hypertrophy and thickening of Bowman's capsule (G), and collections of lymphocytes at the cortical-medullary junction (H), bars = 100 μm.