Figure 6.

Steatosis and lobular inflammation in GP73^tr/tr livers. Compared to normal livers from GP73^+/+ mice (A), livers from male and female GP73^tr/tr mice of average adult weight (31g) frequently showed extensive microvesicular (B) and mixed pattern (C) steatosis, bars = 50 μm. Oil Red O staining revealed extensive lipid accumulation in GP73^tr/tr mice (E and F) compared to weight-matched GP73^+/+ controls (D), bars = 100 μm. Lobular inflammatory infiltrates were also common findings (G), bar = 50 μm. Male and female GP73^tr/tr livers showed nuclei with circumferential membrane irregularities (arrow), and intranuclear inclusions (arrowhead, H). Microvesicular steatosis was also apparent, bar = 10 μm.