Figure 7.

Renal and hepatic abnormalities are associated with upregulated GP73 expression. GP73/β-Geo staining in collecting tubules (A) and in Bowman's capsule of a kidney with hyaline thrombi (B), bars = 50 μm. RT-PCR analysis of GP73 mRNA levels from GP73^+/+ mice (1), GP73^tr/tr mice without renal disease (2), and GP73^tr/tr mice with renal damage (3) (C). GP73/β-Geo staining in hepatocytes of a GP73^tr/tr mouse with nuclear abnormalities (D), bar = 50 μm. RT-PCR of GP73 mRNA expression from livers of GP73^+/+ mice treated with vehicle (control) or CCl₄. (E, F) GP73 mRNA levels from control and CCl₄-treated livers.