Figure 2.
(A) Mean (+ SEM) deoxycorticosterone acetate (DOCA)-induced (10 mg/kg, sc) 0.3 M saline intake plotted as the average daily intake for weeks 1, 2, 3, and 4. DOCA treatment typically induces an increase in saline intake within 2-3 days. DOCA-induced saline intakes were elevated relative to vehicle (VEH)-injected rats at all four time points. (B) Effects of 4 weeks of DOCA treatment (10 mg/kg, sc) on mean arterial pressure (MAP) in rats that have 0.3 M saline continuously available (DOCA-WS), never available during treatment (DOCA-NS), and in vehicle treated rats (VEH). DOCA-WS rats displayed a significantly elevated MAP relative to DOCA-NS and VEH-treated rats. *p<0.05 vs. VEH. †p< .05 vs. DOCA-NS group.