Figure 8. Effects of a CB₁ agonist on the rate of de novo hepatic lipogenesis in mice fed regular diet.

Mice were injected with vehicle (white bars) or 20 ng/g HU-210 i.p. (black bars), and de novo lipogenesis was measured by the rate of incorporation of ³H₂O into hepatic fatty acids, as described in Methods. Note that HU-210 increased lipogenesis in wild-type mice, but not in CB1^–/– or LCB1^–/– mice. *P < 0.05 versus corresponding vehicle-treated control.