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Structural superpositions of Gua38 variants upon WT hairpin ribozymes in the context of 2′-OMe (precatalytic) and 2′,5′ (reaction-intermediate) modifications. (A) The Gua38 variant with a 2′-OMe Ade-1 superimposed on the WT structure. (B) The Gua38 variant with a 2′,5′ modification between Ade-1 and Gua+1 superimposed on the WT structure. The Gua38 base exhibited syn and anti conformations depicted as pink and red, respectively.
