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Putative ternary complex of thrombin, cleaved PAR3 and PAR4 derived from an overlay of the crystal structures of the murine thrombin-PAR4 and thrombin-PAR3 complexes. Thrombin (green) refers to the thrombin-PAR4 complex. Binding of cleaved PAR3 (gold) to exosite I does not interfere with binding of PAR4 (red) to the active site of the enzyme. Cleaved PAR3 may therefore act as a cofactor of PAR4 cleavage by thrombin.
