Table 2.

All Distinct Regions (Clusters) of Lower FA in 41 OSA vs 69 Control Subjects. Location of Maximum Effect is Shown in Montreal Neurological Institute (MNI) Space (mm from Anterior Commissure). Group Mean Values Across All Voxels in Each Cluster are Shown, With Between-Subject Standard Deviations. Some Clusters Encompass Multiple Regions.

Location	MNI coordinates			Voxels	Control	OSA
	X	Y	Z	3.4 mm3	Mean ± SE	Mean ± SE	Figure
Cerebellum/brainstem
caudal pons/middle cerebellar peduncles, corticospinal tract	−3	−23	−45	70	0.2967 ± 0.0057	0.2669 ± 0.0068	Figure 1
cerebellum	−3	−59	−35	52	0.2531 ± 0.0025	0.2407 ± 0.0025	Figure 2A
Thalamus/midbrain/regions adjacent to hippocampus
ventral lateral thalamus adjacent to amygdala and hippocampus	−17	−8	−11	409	0.3721 ± 0.0035	0.3585 ± 0.0057	Figure 2B
midbrain							Figure 3
right fornix column	+5	+3	−5	2	0.2429 ± 0.0034	0.2340 ± 0.0044	Figure 2C
Cingulate cortex/cingulum
inferior longitudinal fasciculus	−44	+2	−24	124	0.2222 ± 0.0025	0.2083 ± 0.0028	Figure 5B
anterior cingulate cortex/superior
cingulum, corpus callosum	−9	+39	−9	2732	0.2537 ± 0.0038	0.2221 ± 0.0030	Figure 4
genu, cingulum	8.3	38	9.7
Posterior inferior-cingulum	+24	−39	−5	9	0.2795 ± 0.0059	0.2537 ± 0.0044	Figure 5A
inferior fronto-occipital fasciculus	−38	−27	0	57	0.3386 ± 0.0032	0.3237 ± 0.0047	Figure 5C
posterior cingulate gyrus	−9	−57	+14	40	0.2494 ± 0.0065	0.2123 ± 0.0057	Figure 5A
posterior cingulate cortex	+3	−53	+32	1517	0.2368 ± 0.0043	0.2089 ± 0.0047	Figure 5A
Deep white matter, insula
right internal capsule	+23	−2	+2	22	0.3579 ± 0.0041	0.3330 ± 0.0047	Figure 5C
left anterior internal capsule	−17	+15	+3	124	0.3446 ± 0.0036	0.3263 ± 0.0054	Figure 5C
right anterior internal capsule	+17	+15	+3	38	0.3164 ± 0.0037	0.2984 ± 0.0063	Figure 5C
posterior internal capsule	−38	−39	+15	10	0.3965 ± 0.0039	0.3757 ± 0.0061
left anterior insula	−36	+17	+2	104	0.1997 ± 0.0021	0.1875 ± 0.0027	Figure 5C
right mid insula	+39	+5	+2	7	0.1975 ± 0.0027	0.1838 ± 0.0026	Figure 5C
Frontal and Prefrontal
left lateral prefrontal	−44	+44	−9	136	0.2182 ± 0.0032	0.1963 ± 0.0039	Figure 6
ventral medial prefrontal	+2	+36	−24	7	0.1482 ± 0.0033	0.1283 ± 0.0032	Figure 6
ventral lateral prefrontal	−29	+18	−24	13	0.1580 ± 0.0044	0.1356 ± 0.0033	Figure 6
medial prefrontal	−8	+59	−11	3	0.2060 ± 0.0074	0.1715 ± 0.0036	Figure 6
right prefrontal	+30	+60	+8	267	0.2223 ± 0.0063	0.1867 ± 0.0040	Figure 6
left medial frontal	−3	+69	+18	1766	0.1697 ± 0.0100	0.1161 ± 0.0040	Figure 6
right lateral frontal	+41	+35	+12	2	0.3236 ± 0.0044	0.2993 ± 0.0047	Figure 6
right frontal	+26	+62	+30	134	0.1335 ± 0.0065	0.0991 ± 0.0040	Figure 6
left lateral frontal	−45	+27	+26	13	0.2823 ± 0.0047	0.2024 ± 0.0046	Figure 6
left deep frontal	−23	+29	+44	4	0.2291 ± 0.0046	0.2059 ± 0.0048	Figure 6
left lateral frontal	−51	+8	+12	26	0.2104 ± 0.0042	0.1876 ± 0.0032	Figure 6
Parietal
right postcentral sulcus	+32	−29	+56	39	0.2633 ± 0.0034	0.2464 ± 0.0042	Figure 6
precentral gyrus	+5	−24	+63	22	0.2394 ± 0.0055	0.2100 ± 0.0060	Figure 6
left central gyrus	−21	−12	+69	4	0.2088 ± 0.0040	0.1917 ± 0.0043
left deep lateral parietal	−51	−50	+5	2	0.2660 ± 0.0048	0.2424 ± 0.0052
left parietal operculum	−45	−18	+15	117	0.1960 ± 0.0031	0.1293 ± 0.0025	Figure 5B
Temporal
superior longitudinal fasciculus	+42	−20	+5	2	0.2450 ± 0.0029	0.2299 ± 0.0044	Figure 5C
left superior temporal gyrus	−39	+21	−24	72	0.1170 ± 0.0024	0.1031 ± 0.0022	Figure 6
left superior temporal gyrus	−23	+9	−26	2	0.1718 ± 0.0038	0.1533 ± 0.0040
inferior longitudinal fasciculus	−45	−41	+17	88	0.2785 ± 0.0033	0.2583 ± 0.0045	Figure 5B
superior temporal gyrus	−59	−39	+17	36	0.1769 ± 0.0031	0.1571 ± 0.0036