Table 2.
Adjusted Cumulative Odds Ratios* and Associated 95% Confidence Intervals (CI) for Impaired Fasting Glucose or Diabetes Across Quartiles of the Apnea-Hypopnea Index (AHI) Using Three Definitions of AHI Based on Associated Level of Oxyhemoglobin Desaturation (ΔSaO2)
| AHI (ΔSaO2 criteria) | AHI cut-points (events/hr) | Impaired fasting glucose (%) | Diabetic fasting glucose (%) | Adjusted cumulative odds ratio (95% CI)* |
|---|---|---|---|---|
| AHI (ΔSaO2: ≥4.0%) | ||||
| Model 1 | ||||
| I | <1.44 | 22.6 | 4.4 | Reference |
| II | 1.44–4.60 | 31.5 | 3.5 | 1.06 (0.82–1.37) |
| III | 4.61–11.37 | 35.5 | 7.1 | 1.32 (1.02–1.71) |
| IV | ≥11.38 | 42.0 | 8.3 | 1.35 (1.04–1.76) |
| AHI (ΔSaO2: 3.0%–3.9%) | ||||
| Model 2 | ||||
| I | <2.25 | 21.8 | 3.2 | Reference |
| II | 2.25–4.37 | 32.3 | 5.3 | 1.53 (1.13–2.06) |
| III | 4.38–7.33 | 35.2 | 6.3 | 1.53 (1.10–2.15) |
| IV | ≥7.34 | 42.2 | 8.4 | 1.72 (1.20–2.48) |
| AHI (ΔSaO2: 2.0%–2.9%) | ||||
| Model 3 | ||||
| I | <4.69 | 25.4 | 3.8 | Reference |
| II | 4.69–7.27 | 30.0 | 4.5 | 0.93 (0.71–1.20) |
| III | 7.27–10.92 | 34.2 | 6.2 | 1.18 (0.90–1.54) |
| IV | ≥10.93 | 42.0 | 8.7 | 1.41 (1.07–1.86) |
| AHI (ΔSaO2: 0.0%–1.9%) | ||||
| Model 4 | ||||
| I | <5.48 | 33.2 | 5.0 | Reference |
| II | 5.48–9.04 | 33.3 | 5.3 | 1.00 (0.79–1.27) |
| III | 9.04–14.69 | 31.3 | 6.5 | 1.06 (0.83–1.34) |
| IV | ≥14.70 | 33.8 | 6.5 | 1.07 (0.84–1.37) |
*
Odds ratio are adjusted for sex, age (quartiles), race (categories), smoking status (former, current, or never), alcohol consumption (none, moderate, heavy), usual sleep duration categories (≤6, 7, 8, ≥9), prevalent hypertension, neck circumference (quartiles), waist circumference (quartiles), body mass index (quartiles), and AHI (quartiles) based on apneas and hypopneas that are associated with more severe desaturation than the upper cut-point of predictor variable.