Figure 2.

Panel A: Daily changes in body weight (g). Two-way ANOVA indicated significant effects of interaction (F_{13, 191} = 6.55; P < 0.0001), treatment (F_{1, 191} = 157.91; P < 0.0001), and day of experiment (F_{13, 191} = 13.99; P < 0.0001). Post testing showed significant differences in body weights between controls and sleep-deprived rats beginning with day 3 until day 10. **P < 0.01, ***P < 0.001. Panel B: Ten days of experiments were divided into equal halves. By day 10, control rats gained an average of 38.4 ± 4 g compared to only 4.4 ± 5.5 g for sleep-deprived rats (t = 4.35, P = 0.049). Note that sleep-deprived rats had significantly lower body weights throughout the experiment compared to controls (KW = 62.88, P < 0.0001). Groups not sharing a common lower-case letter are statistically different from one another at P < 0.05 or less.