Table 3.
Characteristics of Patients with MS without and with RLS
| A. Continuous variables | MS/RLS− | MS/RLS+ | Student t-test | P ≤ |
|---|---|---|---|---|
| Mean ± SD | Mean ± SD | t value | ||
| Age at visit, y | 40.2 ± 10.43 | 45.6 ± 10.60 | −5.82 | 0.000001 |
| Age at MS onset, y | 30.3 ± 9.31 | 34.0 ± 9.55 | −3.98 | 0.00008 |
| MS duration, y | 10.1 ± 8.11 | 12.0 ± 9.37 | −2.32 | 0.02 |
| Sleep latency, min | 19.4 ± 25.06 | 24.7 ± 30.75 | −2.32 | 0.02 |
| Total sleep time, min | 425.1 ± 81.03 | 394.5 ± 86.61 | 4.28 | 0.00002 |
| B. Comparison of frequencies, % | MS/RLS− | MS/RLS+ | χ2 | P ≤ |
|---|---|---|---|---|
| Nap | 35.9 | 37.2 | 0.10 | NS |
| EDS | 28.0 | 43.9 | 15.77 | 0.0001 |
| Insomnia | 20.5 | 41.5 | 31.36 | 0.00001 |
| Bruxism | 11.3 | 14.6 | 1.10 | NS |
| Snoring | 21.7 | 33.9 | 8.34 | 0.004 |
| Leg jerks before sleep | 23.8 | 56.1 | 29.78 | 0.00001 |
| RLS family history | 3.2 | 13.8 | 27.17 | 0.00001 |
| Use of medications | ||||
| None | 86.7 | 75.0 | 13.73 | 0.0002 |
| Hypnotics | 9.9 | 18.3 | 9.19 | 0.0024 |
| Antidepressants | 2.4 | 5.5 | 4.21 | 0.04 |
| Baclofen | 1.0 | 3.0 | 4.04 | 0.045 |
| Other compounds | 0.9 | 1.8 | 1.20 | NS |
MS refers to multiple sclerosis; RLS, restless legs syndrome; ∼EDS excessive daytime sleepiness.