Figure 3. Shannon entropy of nonamer peptides within and across DENV types sequences.

The entropy values were computed from the alignments of DENV sequences using the Antigenic Variability Analyzer software, as described in the Methods . Values were plotted for DENV-1 (A), DENV-2 (B), DENV-3 (C), DENV-4 (D), and all 4 DENV types (E) sequences (2005 dataset). Entropy values around protein cleavage sites are non significant, since the corresponding positions cannot be the center of a nonamer (see Methods ). The triangles below indicate the locations of the pan-DENV sequences in the corresponding proteins.