Figure 7. Candidate putative HLA supertype-restricted, pan-DENV T-cell determinants predicted by computational algorithms.

Amino acid positions of the pan-DENV sequences are numbered according to the sequence alignments of the 4 DENV types; the corresponding DENV proteins are indicated on the left. Predicted HLA-restricted T-cell determinants were identified using NetCTL, Multipred, ARB and TEPITOPE algorithms (see Methods).