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. 2008 Aug 13;3(8):e2942. doi: 10.1371/journal.pone.0002942

Figure 5. The High Bone Mass Phenotype of the DMP1-caPTHR1 Mice is Ameliorated in Mice Lacking the Wnt Co-Receptor LRP5.

Figure 5

(A) Serial analysis of BMD in the femur and spine of LRP5+/+ and LRP−/− mice, with and without the DMP1-caPTHR1 transgene. Both sexes were included. Bars represent the mean±SD of 3–5 mice/group. * p<0.05 vs. LRP5+/+ mice without the transgene. # p<0.05 vs. LRP+/+ mice without the transgene. (B) Von Kossa staining of femurs and lumbar vertebrae of 12-week-old LRP5+/+ and LRP−/− mice, with and without the DMP1-caPTHR1 transgene. (C) High resolution micro-CT scans of distal femora from LRP5+/+ and LRP−/− mice, with and without the DMP1-caPTHR1 transgene.