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. 1998 Nov 10;95(23):13835–13840. doi: 10.1073/pnas.95.23.13835

Figure 3.

Figure 3

Bone resorption parameters in GCV-treated animals. (A) Measurement of osteoclast surface (a) and bone volumes (b) in tibia and vertebrae. Open bars, 10-week-old tg mice untreated; hatched bars, 10-week-old tg mice GCV-treated for 4 weeks; closed bars, 10-week-old wt mice GCV-treated for 4 weeks; gray bars, 14-week-old tg mice 4 weeks after GCV withdrawal. Asterisks indicate statistically significant differences following GCV treatment (P < 0.005; n = 4). (B) Urine deoxypyridinoline crosslinks levels in 10-week-old tg mice untreated or GCV-treated for 4 weeks. (C) Coculture of bone marrow cells (BMCs) and calvarial cells derived from tg mice treated in the absence (−) or presence (+) of GCV for 7 days. (D) Similar coculture assay of BMCs derived from 10-week-old tg mice treated for 4 weeks with GCV. (E) Measurement of bone volume after GCV and/or alendronate treatment of tg animals. Open bar, 10-week-old untreated mice; hatched bar, 10-week-old mice GCV-treated for 4 weeks; light gray bar, 10-week-old mice treated with alendronate (Al.) for 4 weeks; dark gray bar, 10-week-old mice treated with GCV and alendronate for 4 weeks. (F) Similar structural appearance of tibia of 10-week-old mouse untreated (a) or treated with GCV and alendronate for 4 weeks (b).