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. 1998 Nov 10;95(23):13835–13840. doi: 10.1073/pnas.95.23.13835

Figure 4.

Figure 4

Induction of osteoporosis of variable severity. Tg animals aged 12 weeks were GCV-treated for 4–8 weeks. (A) Histological analysis of tibiae of 16-week-old mice untreated (a); 16-week-old mice GCV-treated for 4 weeks (b); 20-week-old mice GCV-treated for 8 weeks (c). Note the progressive loss of trabecular bone. (B) Static and dynamic histomorphometric analyses. Measurement of bone formation rate (a) and bone volume (b). Open bars, 16-week-old animal untreated; hatched bars, 16-week-old animals GCV-treated for 4 weeks; closed bars, 20-week-old animals GCV-treated for 8 weeks. For each parameter similar values were observed in 16-week-old and 20-week-old untreated animals. Asterisks indicate statistically significant differences between wt and tg mice (P < 0.01; n = 4).