Table 1.
Clinical and Laboratory Data of All Studied Cases [18]
| Variables | Controls (n = 15) | CHC Without Cirrhosis (n = 50) | CHC With Cirrhosis (n = 30) | HCC With HCV (n = 30) |
|---|---|---|---|---|
| Age | 42.8 ± 6.6 | 42.4 ± 9.3 | 45.1 ± 5.9 | 48.9 ± 7.2 |
| Gender (M:F) | 2:1 | 4:1 | 17:13 | 5:1 |
| Clinical findings: n (%) | ||||
| Pallor | 0 (0) | 2 (4%) | 5 (16.5%) | 8 (26.6%) |
| Jaundice | 0 (0) | 3 (6%) | 6 (20%) | 13 (43.3%) |
| Palmar erythema | 0 (0) | 0 (0) | 15 (50%) | 17 (56.6%) |
| Spider nevi | 0 (0) | 0 (0) | 14 (46.6%) | 14 (46.6%) |
| Lower-limb edema | 0 (0) | 0 (0) | 16 (53.3%) | 9 (30%) |
| Child-Pugh classification | ||||
| A | 10 (100%) | 50 (100%) | 8 (26.6%) | 1 (3.3%) |
| B | 0 (0) | 9 (30%) | 11 (36.6%) | |
| C | 0 (0) | 13 (43.3%) | 18 (60%) | |
| Ultrasound findings: n (%) | ||||
| Hepatomegaly | 0 (0) | 21 (42%) | 12(40%) | 20(66.6%) |
| Liver echogenicity | ||||
| *Normal | 0 (0) | 26 (52%) | 10(33.3%) | 4 (13.3%) |
| *Hyperechoic | 0 (0) | 24 (48%) | 20(66.6%) | 26 (86.6%) |
| Liver function tests (mean ± SD) | ||||
| AST (U/L) | 8.09 ± 2.11 | 14.91 ± 5.32 | 11.42 ± 4.12 | 18.90 ± 6.47 |
| ALT (U/L) | 7.73 ± 2.04 | 15.09 ± 6.80 | 12.18 ± 5.33 | 16.38 ± 6.32 |
| Alkaline phosphatase (U/L) | 189 ± 60 | 331 ± 77 | 348 ± 69 | 420 ± 72 |
| Albumin (g/dL) | 4.01 ± 0.38 | 3.60 ± 0.85 | 3.80 ± 0.72 | 3.08 ± 0.48 |
| PT concentration | 97.6 ± 3.4 | 89.7 ± 5.8 | 41.4 ± 11.2 | 68.5 ± 3.8 |
| Alpha-fetoprotein (IU/mL) | 3.39 ± 2.9 | 9.36 ± 13.6 | 10.41 ± 15.6 | 25.04 ± 27.9 |
Normal range for ALT and AST: up to 12 U/L; for alkaline phosphatase: up to 250 U/L; for albumin: 3.5–5 g/dL.
Normal range of prothrombin concentration: 85%–100%.
Normal range for alpha-fetoprotein: 0.1–9.6 IU/mL.