. Author manuscript; available in PMC: 2009 Jul 1.

Published in final edited form as: Expert Opin Ther Pat. 2008 Jul;18(7):723–738. doi: 10.1517/13543776.18.7.723

Table 2.

Presently used biologic DMARDs

Drug	Status	Properties
Infliximab	Approved for RA 1999(US)	Chimeric IgG1 anti-TNF-α antibody
Etanercept	Approved 1998 (US)	Soluble TNF-receptor fusion protein
Adalimumab	Approved 2002 (US)	Human monoclonal antibody to TNF
Anakinra	Approved 2001 (US)	Recombinant IL-1 inhibitor
Abatacept	Approved 2005 (US)	Costimulation blockers
Rituximab	Approved for RA 2006 (US)	Chimeric anti-CD20 monoclonal antibody
Tocilizumab	Filed for approval in Japan	Human antibody against IL-6 receptor