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Growth curves of papillomas following infection with wild type and codon-optimized genomes. E7/8 and E7/14 papillomas grew at about wild type rate; E7/18 papillomas grew statistically faster than E7/22 papillomas (P<0. 001, unpaired student's t test); E7/18 papillomas grew statistically faster at later time points than wild type papillomas (P<0.03 unpaired student's t test).
