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. 2008 Aug 13;3(8):e2947. doi: 10.1371/journal.pone.0002947

Table 1. E7 immunization resulted in reduced papilloma size.

Genome % reduction in papilloma size by E7 immunization
week 8 week 11
Wild type 45% 36%
E7/8 40% 30%
E7/14 38% 31%
E7/18 53% 43%
E7/22 74% 75%

Immunization of animals with wild type E7, followed by infection with wild type and four codon-optimized genomes, resulted in reduction in size of papillomas. Two time points (8 and 11 weeks) after infection are presented. The effect was most notable with E7/22 for which a 75% reduction in size was measured.