Table 1. E7 immunization resulted in reduced papilloma size.
Genome | % reduction in papilloma size by E7 immunization | |
week 8 | week 11 | |
Wild type | 45% | 36% |
E7/8 | 40% | 30% |
E7/14 | 38% | 31% |
E7/18 | 53% | 43% |
E7/22 | 74% | 75% |
Immunization of animals with wild type E7, followed by infection with wild type and four codon-optimized genomes, resulted in reduction in size of papillomas. Two time points (8 and 11 weeks) after infection are presented. The effect was most notable with E7/22 for which a 75% reduction in size was measured.