Table 12 Anorexic premenopausal women: negative effect of oral contraceptives on bone mineral density.

Study design	Reference	No of patients	OC exposure	Measurement of BMD/bone metabolism	Results
Cohort (level 2b)	Kreipe et al79	4 women with AN (ages 17–28)	Oestrogen + progestin replacement (n = 2) v control (n = 2) for 6 months	Lumbar spine DXA	1.9% decrease in BMD in oestrogen‐progestin treated group v 1.3% increase in BMD in control group

OC, Oral contraceptive; BMD, bone mineral density; AN, anorexia nervosa; DXA, dual energy x ray absorptiometry.