Table 9 Oligo/amenorrhoeic premenopausal women: negative effect of oral contraceptives on bone mineral density.

Study design	Reference	No of patients	OC exposure	Measurement of BMD/bone metabolism	Results
Case report	Zanker et al71	1 amenorrhoeic athlete (followed between age 24.8 to 36. 9 years)	For the first 5 years, used 30 μg EE+150 μg desogestrel	Lumbar spine, proximal femur DXA	9.8% decrease in lumbar spine BMD and 12.1% decrease in proximal femur BMD during 5 years of OC use

OC, Oral contraceptive; BMD, bone mineral density; EE, ethinyl oestradiol; DXA, dual energy x ray absorptiometry.