Figure 2.

Bargraphs showing ≈2-fold increases in the mean number of catalase immunogold particles within astrocytes (astro), oligodendrocytes (oligo), microdendroglia (micro), axons, and endothelia (endo) with inoculations of rAAV-Cat (A). Bargraphs showing catalase inoculations had the following effects on EAE: reduced demyelination (increased myelin areas) (B), reduced optic nerve head edema (smaller areas) (C), decreased optic nerve cell count (D), reduced extravasated immunogold-labeled serum albumin (suppressed disruption of the BBB) (E), and reduced in vivo levels of H₂O₂ in the optic nerve head (ONH), retrobulbar optic nerve (RON) and the optic nerve sheath (ONS) (F). ∗, statistically significant.