Table 4.
Analysis of gene-gene interactions of new type 1 diabetes loci with known disease loci
| New T1D loci | ||||||
|---|---|---|---|---|---|---|
| Gene | rs number | 12q24 SH2B3 rs3184504 |
18p11 PTPN2 rs1893217 |
18p11 PTPN2 rs478582 |
12q13 ERBB3 rs2292239 |
16p13 KIAA0350 rs12708716 |
| HLA class II | (11d.f.) | 0.780 (2,347) |
0.811 (2,527) |
0.973 (2,488) |
0.307 (2,551) |
0.142 (2,554) |
| INS | rs689 | 0.602 (3,839) |
0.333 (4,081) |
0.299 (4,077) |
0.904 (3,616) |
0.233 (4,174) |
| PTPN22 | rs2476601 | 0.529 (4,970) |
0.631 (5,270) |
0.537 (5,286) |
0.0240 (4,695) |
0.659 (5,380) |
| CD25 | ss52580109 | 0.264 (4,816) |
0.638 (5,076) |
0.752 (5,087) |
0.747 (4,519) |
0.244 (5,188) |
| CD25 | rs11594656 | 0.407 (4,764) |
0.341 (5,023) |
0.487 (5,050) |
0.471 (4,481) |
0.457 (5,133) |
| CTLA4 | rs3087243 | 0.600 (3,806) |
0.955 (4,043) |
0.989 (4,044) |
0.359 (3,580) |
0.922 (4,137) |
| IFIH1 | rs1990760 | 0.777 (5,147) |
0.362 (5,463) |
0.825 (5,484) |
0.877 (5,075) |
0.104 (5,589) |
| Sex | 0.355 (5,338) |
0.422 (5,674) |
0.849 (5,699) |
0.683 (5,371) |
0.776 (5,804) |
|
| Age at diagnosis |
0.0153 (5,338) |
0.450 (5,674) |
0.396 (5,699) |
0.139 (5,371) |
0.715 (5,804) |
|
Data represent P values (with the number of affected individuals in parentheses).