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Protection against SHIV vaginal challenge by vaginally applied T-1249. T-1249 was formulated in HMC gel and applied vaginally to macaques at the concentrations indicated on the x axis 30 min before challenge with SHIV-162P3 (A), SHIV-89.6P (B), or SHIV-KU1 (C). The proportion of the test animals that became infected at each T-1249 concentration is shown on the y axis. The figure in parentheses adjacent to each data point records the number of animals used to derive the recorded value.
