Table 1.
Inhibition of SHIV and SIVmac replication in human and rhesus PBMC
| Virus | CMPD-167 | AMD3465 | CMPD + AMD** | T-1249 | C52L | BMS-C |
|---|---|---|---|---|---|---|
| SHIV-KU1 | >1,000* | 2.2 (7.6) | 1.0 | 0.90 (1.4) | 5.9 | 0.20 |
| SHIV-89.6P | >1,000 | 1.3 (<1.6) | 0.42 | 0.77 (1.9) | 5.3 | 0.30 |
| SHIV-162P3 | 0.30 | >1,000 | 0.80 | 3.9 | 13 | 0.20 |
| SHIVmac | 0.80 | >1,000 | 1.5 | 3.5 | 4.8 | >1,000 |
*Inhibition of replication in pooled human PBMCs is shown as IC50 concentrations (nM) that were derived from four-parameter sigmoid fits by nonlinear regression. The values in parentheses were generated using rhesus PBMCs.
**CMPD-167 and AMD3465 in a 1:5 mix; the total concentration is given.